野马追内酯A T5826

Product Introduction
Bioactivity


英文名: Eupalinolide A

描述: Eupalinolide A 是分离于林泽兰中的一种天然产物，通过抑制 HSF1 与 HSP90 的相互作用，激活 HSF1，诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。

体外活性: Eupalinolide B and A (EB and EA) from E. lindleyanum, and describe their actions as HSP-inducers.?EA and EB both induced the expression of HSP70 in cells at concentrations that did not significantly affect cell viability.?Treatment of cells with EA or EB activated heat shock factor 1 (HSF1), while the artificial suppression of HSF1 expression diminished the EA- or EB-mediated induction of HSP70 expression.?Furthermore, EB inhibited the interaction between HSF1 and HSP90, which is known to inhibit the activity of HSF1.?Suggest that EA and EB induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90.?EA and EB both induced the expression of HSP70 synergistically with other stressors.?Furthermore, pre-treatment of cells with EA or EB suppressed melanin production and stressor-induced apoptosis.?These effects were suppressed by the artificial suppression of HSP70 expression.?In vivo, the percutaneous administration of EB induced the expression of HSP70 and suppressed UVB radiation-induced damage, inflammatory responses and melanin production in the skin.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (108.11 mM)


关键字: Eupalinolide A | responses | inflammatory | HSF1 | expression | HSP | Inhibitor | production | UV-induced | melanin | skin | damage | Heat shock proteins | inhibit

相关产品: CH5138303 | Radicicol | Novobiocin | VER49009 | HSP90-IN-25 | CC-99677 | Rocaglamide | KW-2478 | Alvespimycin | Pifithrin-μ

相关库: Anti-Tumor Natural Product Library | HIF-1 Signaling Pathway Compound Library | Anti-Cancer Compound Library | Selected Plant-Sourced Compound Library | Covalent Natural Product Library | Chinese Pharmacopoeia Natural Product Library | Cytoskeletal Signaling Pathway Compound Library | Traditional Chinese Medicine Monomer Library | Metabolism Compound Library | Exosome Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途