亚硫酸氢钠甲萘醌 T5963

Product Introduction
Bioactivity


英文名: Menadione bisulfite sodium

描述: Menadione bisulfite sodium (Vitamin K3 sodium bisulfite) 是可以诱导急性氧化应激的试剂，可用作植物防御活化剂，具有抵抗病菌的作用。

体外活性: MSB inhibited Aβ42 amyloid formation in a dose dependent manner, delayed the secondary structural conversion of Aβ42 from random coil to ordered β-sheet, and attenuated the ability of Aβ42 aggregates to disrupt membranes; moreover, the quinone backbone rather than lipophilicity is esstial for the inhibitory effects of MSB. Next, in cells expressing a pathogenic APP mutation (Osaka mutation) that results in the formation of intraneuronal Aβ oligomers, MSB inhibited the intracellular aggregation of Aβ. Moreover, MSB treatment significantly extended the life span of Caenorhabditis elegans CL2120, a strain that expresses human Aβ42. Together, these results suggest that MSB and its derivatives may be further explored as potential therapeutic agents for the prevention or treatment of Alzheimer's disease(AD)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/mL (72.4 mM)


关键字: Menadione bisulfite | Vitamin K3 sodium Bisulfite | Sodium menadione Bisulfite | inhibit | Menadione bisulfite sodium | Inhibitor | Menadione sodium Bisulfite

相关库: Drug Repurposing Compound Library | Approved Drug Library | Oxidation-Reduction Compound Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | NMPA-Approved Drug Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途