去甲蟛蜞菊内酯 T5S0689

Product Introduction
Bioactivity


英文名: Demethylwedelolactone

描述: Demethylwedelolactone 是一种分离自 Eclipta alba 中的 coumestan 天然产物。它能抑制乳腺癌细胞的移动和侵袭，是一种有效的trypsin 抑制剂(IC50:3.0 μM)。

体外活性: demethylwedelolactone (DWEL) inhibited the anchorage-independent growth and also suppressed cell motility and cell invasion of MDA-MB-231 cells.DWEL reduced the activity and expression of matrix metalloproteinases (MMPs) involved in blocking the IκB-α/NFκB and MEK/ERK signaling pathways in MDA-MB-231 cells.?Furthermore, DWEL suppressed the metastasis and lung colonization of the tumor cells in the nude mice.?DWEL derivatives exert anti-invasive growth effect on breast cancer cells.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (74.95 mM)


关键字: Inhibitor | Demethylwedelolactone | inhibit | Ser/Thr Protease | Serine proteases | Threonine proteases | Serine endopeptidases

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相关库: Anti-Cancer Compound Library | Polyphenolic Natural Product Library | Selected Plant-Sourced Compound Library | Bioactive Compounds Library Max | Chinese Pharmacopoeia Natural Product Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library

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