芹菜素-7-葡萄糖醛酸 T5S1026
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 29741-09-1 | ¥5,470.00 | 询底价 |
10 mg | 29741-09-1 | ¥1,550.00 | 询底价 |
1 mL | 29741-09-1 | ¥987.00 | 询底价 |
50 mg | 29741-09-1 | ¥3,830.00 | 询底价 |
5 mg | 29741-09-1 | ¥953.00 | 询底价 |
25 mg | 29741-09-1 | ¥2,620.00 | 询底价 |
1 mg | 29741-09-1 | ¥388.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Apigenin-7-glucuronide
描述: Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性,其对 MMP-3 (IC50:12.87 μM),MMP-8 (IC50:22.39 μM),MMP-9 (IC50:17.52 μM),MMP-13 (IC50:0.27 μM)。
体内活性: Apigenin-7-O-β-D-glucuronide (AG) suppressed the release of nitric oxide (NO), prostaglandin E2 (PGE2), and tumour necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages in a dose-dependent manner without affecting cell viability. Additionally, AG suppressed LPS-induced mRNA expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-α. AG treatment decreased the translocation of c-Jun into the nucleus and decreased activator protein-1 (AP-1)-mediated luciferase activity through the inhibition of both p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) phosphorylation [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (112.02 mM)
关键字: inhibit | Matrix metalloproteinases | Inhibitor | Apigenin7glucuronide | MMP | Apigenin 7 glucuronide | Apigenin-7-glucuronide
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途