9-甲氧基喜树碱 T5S1952

Product Introduction
Bioactivity


英文名: 9-Methoxycamptothecin

描述: 9-Methoxycamptothecin 是从臭味假柴龙树中分离得到的一种天然产物，通过抑制拓扑异构酶起到抗肿瘤作用，具有强效的诱导 G2/M 期细胞和癌细胞凋亡的作用。

体外活性: 9-Methoxycamptothecin(MCPT) induced cytotoxicity in seven human cancer cell lines in a dose dependent manner after 72h, with A2780 and Hela cell lines more sensitive, so the two cell lines were chosen to do further studies. MCPT induced strong G2/M arrest in both A2780 cells and Hela cells after 24h, following by substantial sub-G1 arrest (indicating apoptosis). The apoptosis was verified by staining with Annexin V-FITC and propidium iodide. ROS generation increased significantly in MCPT-induced apoptosis. Meanwhile, the apoptosis appeared to be dependent on caspase-3, -8 and -9 in A2780 cells, and caspase-3 in Hela cells. In addition, MCPT induced up-regulation expression of most of seventeen genes in both cell lines. Western blot verified that changes of TNFα, Fas, P53 and P27 protein level were consistent with their gene expression changes[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (132.14 mM)


关键字: Inhibitor | Apoptosis | 9 Methoxycamptothecin | inhibit | Topoisomerase | 9Methoxycamptothecin | 9-Methoxycamptothecin

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