化合物ANT3310 T60050
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 2410688-61-6 | ¥2,830.00 | 询底价 |
5 mg | 2410688-61-6 | ¥823.00 | 询底价 |
100 mg | 2410688-61-6 | ¥5,890.00 | 询底价 |
10 mg | 2410688-61-6 | ¥1,370.00 | 询底价 |
50 mg | 2410688-61-6 | ¥4,220.00 | 询底价 |
1 mL | 2410688-61-6 | ¥882.00 | 询底价 |
1 mg | 2410688-61-6 | ¥348.00 | 询底价 |
Product Introduction
Bioactivity
英文名: ANT3310
描述: ANT3310 是一种广谱共价丝氨酸 β-内酰胺酶抑制剂,对 AmpC、CTX-M-15、TEM-1、OXA-48、OXA-23 和 KPC-2 的 IC50 范围为 1 nM 至 175 nM。 ANT3310 可用于细菌感染研究。
体外活性: ANT3310 shows a low in vitro cytotoxicity (IC50 > 100 μM), cardiotoxicity (inhibition of the hERG potassium ion channel) and genotoxicity in HepG2 cell. ANT3310 (0.006 to 3 000 nM) inhibits a series of Serine β-Lactamase including AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2, with IC<>50 values ranging from 1 nM to 175 nM[1].
体内活性: In male Swiss albino mice, ANT3310 (1 mg/kg; i.v.) shows a T1/2 value of 0.64 h, AUC value of 412 ng•h/mL, and Cl value of 40 mL/min/kg. In the murine thigh infection model, ANT3310 (25, 50 and 100 mg/kg; i.v.) reduces bacterial burdens in a dose-dependent manner to levels below that of the initial starting inoculum at the highest dose, when treated with the combination of MEM[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (190.7 mM)
关键字: ANT 3310 | inhibit | SBL | ANT3310 | infection | CRE | β-lactam antibiotic | Bacterial | ANT-3310 | OXA enzymes | DBOs | Inhibitor | CRAB
相关产品: WCK-5153 | Sulfisoxazole | Thio-TEPA | Omeprazole Sodium | Ceftobiprole medocaril | Ciprofloxacin monohydrochloride | Sulfaphenazole | Ampicillin sodium | Doxycycline hydrochloride | Berberine
相关库: Bioactive Compounds Library Max | Inhibitor Library | Anti-Bacterial Compound Library | Bioactive Compound Library
化合物ANT3310 T60050信息由TargetMol中国为您提供,如您想了解更多关于化合物ANT3310 T60050报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途