化合物HDAC-IN-40 T60082

Product Introduction
Bioactivity


英文名: HDAC-IN-40

描述: HDAC-IN-40 是一种有效的基于烷氧基酰胺的 HDAC 抑制剂，对 HDAC2 和 HDAC6 的 Ki 分别为 60 nM 和 30 nM。HDAC-IN-40 具有抗肿瘤作用。

体外活性: HDAC-IN-40 shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 µM and 0.72 µM, respectively. HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR. HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 200 mg/mL (612.9 mM)


关键字: HDACIN40 | HDAC IN 40 | HDAC-IN-40

相关产品: NKL 22 | Rac-Belinostat | ACY-957 | CAY10603 | SR-4370 | HDAC8-IN-20a | CHDI-390576 | EDO-S101 | 4-Phenylbutyric acid | BRD 4354

相关库: NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Anti-Pancreatic Cancer Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Chromatin Modification Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途