化合物SAR 131675 T6012

Product Introduction
Bioactivity


英文名: SAR131675

描述: SAR131675 是一种选择性的VEGFR3抑制剂，其IC50=23 nM。

体外活性: KU-0060648 exhibits differential effects on growth inhibition, but is not profoundly cytotoxic in a panel of human cancer cell lines. It inhibits DNA-PK and PI-3K with greater potency in MCF7 than SW620 cell using cell-based assays. Five-day exposure to 1 mM KU-0060648 inhibits cell proliferation by more than 95% in MCF7 cells but only by 55% in SW620 cells. In clonogenic survival assays, KU-0060648 increases the cytotoxicity of etoposide and doxorubicin across the panel of DNA-PKcs-proficient cells, but not in DNA-PKcs-deficient cells, confirming that enhanced cytotoxicity of the topoisomerase II poisons etoposide and doxorubicin is due to DNA-PK inhibition. [1]

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 16.67 mg/mL (46.51 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: VEGFR | Inhibitor | SAR131675 | Vascular endothelial growth factor receptor | SAR-131675 | inhibit

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