吉米替康 T60123

Product Introduction
Bioactivity


英文名: Chimmitecan

描述: Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) 是一种topoisomerase I 抑制剂，在体内、外表现有效的活性。

体外活性: Chimmitecan was highly cytotoxic (IC50s in the nanomolar range) to a wide variety of tumor cells, including leukemia, lung cancer, gastric cancer, hepatocellular cancer, colon cancer, breast cancer, ovarian cancer, and cervical cancer, and rhabdomyosarcoma cells[1].

体内活性: Chimmitecan (i.v. administration, twice for HCT-116 and thrice for the other tumors per week) caused a dramatic and dose-dependent suppression of tumor growth in all four tumor models. At a dosage of 15 mg/kg, the T/C (%) values were 17.6% (HCT-116), 24.2% (MDA-MB-435), 28.2% (BEL-7402), and 23.0% (A549). when given thrice per week for 2 weeks, chimmitecan (orally administration) inhibited the growth of the A549 xenograft at dosages as low as 4.5 mg/kg, and significant antitumor activity was observed at a dosage of 9 mg/kg[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.05 mg/mL (10 mM)


关键字: 9-Allyl-10-hydroxycamptothecin | Chimmitecan

相关产品: Aldoxorubicin | Cinoxacin | Podofilox | Topoisomerase II inhibitor 16 | Nalidixic acid | Gatifloxacin hydrochloride | Topoisomerase inhibitor 2 | Irinotecan | Pefloxacin Mesylate | Nitidine chloride

相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library

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