化合物UNC 1025 T60197
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 1350549-36-8 | ¥2,590.00 | 询底价 |
100 mg | 1350549-36-8 | ¥7,560.00 | 询底价 |
50 mg | 1350549-36-8 | ¥5,610.00 | 询底价 |
25 mg | 1350549-36-8 | ¥4,150.00 | 询底价 |
1 mg | 1350549-36-8 | ¥774.00 | 询底价 |
1 mL | 1350549-36-8 | ¥1,980.00 | 询底价 |
500 mg | 1350549-36-8 | ¥15,100.00 | 询底价 |
5 mg | 1350549-36-8 | ¥1,730.00 | 询底价 |
Product Introduction
Bioactivity
英文名: UNC 1025
描述: UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. Notably, UNC1062 demonstrates potent inhibition of MERTK kinase activity, with an IC50 of 1.1 nM and a Morrison Ki of 0.33 nM. It also displays specificity within the TAM family, exhibiting IC50 values of 60 nM for TYRO3 and 85 nM for AXL [1].
体外活性: UNC1062 potently inhibits MERTK kinase activity in vitro (MERTK IC50 = 1.1 nM, Morrison Ki = 0.33 nM) and exhibits specificity within the TAM family (TYRO3 IC50 = 60 nM, AXL IC50 = 85 nM). Treatment of HMCB and G361 cells with increasing concentrations of UNC1062 resulted in a potent dose-dependent reduction in MERTK phosphorylation[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (106.87 mM)
关键字: UNC-1025 | UNC1025 | UNC 1025
相关库: Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途