化合物 Acloproxalap T60238

Product Introduction
Bioactivity


英文名: Acloproxalap

描述: Acloproxalap 是一种基于喹啉的醛清除剂，可用于研究有毒醛积累的疾病，如眼部、皮肤等炎症性疾病，肺炎等呼吸系统疾病，器官疾病以及病毒感染相关性综合症等。

体内活性: Acloproxalap (compound I-6) (100 or 200 mg/kg, i.p. or p.o., everyday, 6 days) can effectively ameliorate inflammation of the colon in acute ulcerative colitis (UC) female Swiss Webster mice [1]. Animal Model: Acute ulcerative colitis (UC) in female Swiss Webster mice [1] Dosage: 100 mg/kg, 200 mg/kg Administration: Intraperitoneal injection for 100 mg/kg, oral gavage for 200 mg/kg; everyday; 6 days Result: Inhibited weight loss in intraperitoneal injection mice significantly while there was no significant difference in the oral gavage group compared to the control group. Both significantly reduced colonic histopathological parameters. Animal Model: Male non-na ve beagle dogs [2] Dosage: 3 mg/kg Administration: Intravenous injection; once Result: The pharmacokinetic parameters of Acloproxalap (compound I-1) Parameter Acloproxalap (compound I-1) t 1/2 1.82 h T max 0.518 h Clearance 12.2 mL/kg/min steady-state volume 1385 mL/kg AUC 0-t 4103 ng/mL*h AUC 0 inf_obs 4137 ng/mL*h Animal Model: Male non-na ve beagle dogs [2] Dosage: 10 mg/kg Administration: Oral gavage; once Result: The pharmacokinetic parameters of Acloproxalap (compound I-1) Parameter Acloproxalap (compound I-1) t 1/2 3.02 h T max 0.518 h C max 3558 ng/mL AUC 0-t 9361 ng/mL*h AUC 0 inf_obs 9546 ng/mL*h BioA 75%

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途