化合物PF-3845 T6043
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1196109-52-0 | ¥2,970.00 | 询底价 |
1 mL | 1196109-52-0 | ¥425.00 | 询底价 |
2 mg | 1196109-52-0 | ¥268.00 | 询底价 |
10 mg | 1196109-52-0 | ¥772.00 | 询底价 |
100 mg | 1196109-52-0 | ¥4,580.00 | 询底价 |
25 mg | 1196109-52-0 | ¥1,580.00 | 询底价 |
5 mg | 1196109-52-0 | ¥423.00 | 询底价 |
Product Introduction
Bioactivity
英文名: PF-3845
描述: PF3845 是一种有效的、选择性的和不可逆的脂肪酸酰胺水解酶(FAAH)抑制剂,Ki 为 230 nM。它是将 FAAH 的丝氨酸亲核试剂氨基甲酸酯化的共价抑制剂,可以减少疼痛感、炎症和焦虑或抑郁。
体外活性: PF-3845 selectively inhibits FAAH by carbamylating FAAH's serine nucleophile. [1]
体内活性: PF-3845 treated mice (10 mg/kg, i.p.) shows rapid and complete inactivation of FAAH in the brain, as judged by competitive activity-based protein profiling (ABPP) with the serine hydrolase-directed probe fluorophosphonate (FP)-rhodamine. PF-3845 shows a long duration of action up to 24 hour. PF-3845-treated mice also shows dramatic (>10-fold) elevation in brain levels of AEA and other NAEs (N-pamitoyl ethanolamine [PEA] and N-oleoyl ethanolamine [OEA]). FAAH is AEA-degrading enzyme fatty acid amide hydrolase. PF-3845 (1–30 mg/kg, oral administration [p.o.]) causes a dose dependent inhibition of mechanical allodynia with a minimum effective dose (MED) of 3 mg/kg (rats are analyzed at 4 hour post dosing with PF-3845). At higher doses (10 and 30 mg/kg), PF-3845 inhibits pain responses to an equivalent, if not greater, degree than the nonsteroidal anti-inflammatory drug naproxen (10 mg/kg, p.o.). [1] PF-3845 (10 mg/kg, i.p.) significantly reverses LPS-induced tactile allodynia, but doesn't modify paw withdrawal thresholds in the saline-injected paw. [2]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 100 mg/mL (219 mM)
Ethanol : 22.8 mg/mL (50 mM)
关键字: PF-3845 | Inhibitor | PF 3845 | Autophagy | inhibit | depression | hydrolase | anxiety | PF3845 | FAAH | Fatty acid amide hydrolase | sensation | pain | fatty | amide | inflammation | acid
相关产品: PDP-EA | N-Benzyllinolenamide | 4-Nonylphenylboronic acid | AA38-3 | ARN272 | URB937 | Palmitoylisopropylamide | URB-597 | JZL195 | JP104
相关库: Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Highly Selective Inhibitor Library | Lipid Metabolism Compound Library | Metabolism Compound Library | Orally Active Compound Library | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途