化合物 Lanicemine dihydrochloride T60471

Product Introduction
Bioactivity


英文名: Lanicemine dihydrochloride

描述: Lanicemine (AZD6765) dihydrochloride 是NMDA 通道的低捕获拮抗剂，Ki 值为 0.56-2.1 μM，在CHO 和爪蟾卵母细胞的IC50分别为 4-7 μM 和 6.4 μM。Lanicemine (AZD6765) dihydrochloride 具有持续的抗抑郁功效。

体内活性: Lanicemine is a low-trapping NMDA channel blocker that produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1]. Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits that generate the gamma- electroencephalography (EEG), but affects these networks without the broader systems-level disruptions typical of ketamine [1]. Animal Model: Male Sprague-Dawley rats [1] Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: A clear dose-dependent elevation in spontaneous gamma-band EEG was produced, but only gamma changes for Ketamine were strongly associated with increases in locomotor activity.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途