化合物 Pilsicainide T60482

Product Introduction
Bioactivity


英文名: Pilsicainide

描述: Pilsicainide (SUN 1165 free acid)是一种有效的 Ic 类抗心律失常药。Pilsicainide 是一种有效的钠通道阻滞剂。

体外活性: Pilsicainide (SUN 1165 free acid; 10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC 50 of 29.2 μg/mL in levo-thyroxine (T 4 )-treated rat atrial cells [1].

体内活性: Pilsicainide (SUN 1165 free acid; 2 mg/kg; i.v.; once) decreases the conduction velocity in T 4 -treated rat atrium by decreasing the Max dV/dt and net inward current [1]. Animal Model: Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T 4 ) treatment [1] Dosage: 2 mg/kg Administration: Bolus injection into right external carotid vein within 2 minutes, once Result: Elongated the QT interval at 15 and 60 minutes after administration. Shortened P wave and QRS complex durations. Markedly decreased action potential amplitudes (APA) and Max dV/dt, and significantly lengthened the action potential durations.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途