化合物 MFI8 T60503

Product Introduction
Bioactivity


英文名: MFI8

描述: MFI8 是一种调控线粒体裂变的化合物，可用于研究衰老。

体外活性: At a concentration of 20 μM for a duration of 6 hours, MFI8 significantly reduces mitochondrial aspect ratio with an EC50 of 4.8 μM. It achieves this by inhibiting mitochondrial function through mitofusins, subsequently promoting mitochondrial fission [1].MFI8 possesses functional groups that adhere to the pharmacophore model standards. It interacts with mitofusins, facilitating mitochondrial fission [1].Binding to the HR2 domain of MFN2, MFI8 modulates MFN conformation and complexes, thereby altering mitochondrial function [1].In a concentration-responsive manner (0-20 μM; 6 hours), MFI8 increases caspase-3/7 activity, induces cytochrome c release, and reduces membrane potential in a mitotic protein-dependent manner. Additionally, the combination of MFI8 with BV6 SMAC, a mimic of the second mitochondrial-derived activator of caspases, induces DNA damage and cell death [1].

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 80 mg/mL (290.10 mM)


相关产品: 4-methyl-6-phenyl-2H-pyranone | IMT1 | MSDC 0160 | L-Histidine | Rotenone | D-Histidine | Agaric acid | 7ACC2 | Lonidamine | BTM-3528

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途