PI3K/Akt/mTOR抑制剂2 T60564

Product Introduction
Bioactivity


英文名: PI3K/Akt/mTOR-IN-2

描述: PI3K/Akt/mTOR-IN-2 是一种有效的 PI3K/AKT/mTOR 抑制剂。PI3K/Akt/mTOR-IN-2 具有抗癌作用，并对 MDA-MB-231 细胞具有选择性，IC50 为 2.29 μM。PI3K/Akt/mTOR-IN-2 具有抗癌活性，可诱导癌细胞周期阻滞和细胞凋亡 (apoptosis)。

体外活性: PI3K/Akt/mTOR-IN-2 (compound 23) (0.5 - 100 μM; 72 h) demonstrates significant anti-cancer efficacy, with IC50 values ranging from 2.29 to 24.63 μM. Notably, its IC50 in MDA-MB-231 cells is 2.29 μM.[1]PI3K/Akt/mTOR-IN-2 (1, 2 and 4 μM; 24 h) induces growth inhibition of MDA-MB-231 cells by cell cycle arrest at G0/G1.[1]PI3K/Akt/mTOR-IN-2 (1, 2, and 4 μM; 24, 48, and 72 h) elicits apoptosis in MDA-MB-231 cells in a manner that is both dose- and time-dependent.[1]PI3K/Akt/mTOR-IN-2 (1, 2, and 4 μM; 48 h) increases the expression of Bax and decreases the expression of Bcl-2 in MDA-MB-231 cells.[1]PI3K/Akt/mTOR-IN-2 (1, 2, and 4 μM; 24 h) triggers mitochondria-dependent apoptosis in MDA-MB-231 cells by perturbing mitochondrial membrane potential (MMP), causing an increase in reactive oxygen species (ROS), reducing intracellular glutathione (GSH) levels, and elevating intracellular calcium ion (Ca2+).[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 28.53 mg/mL (100 mM)


相关产品: Tubulin inhibitor 11 | Scopoletin | Vistusertib | Vorinostat | BIO-acetoxime | Stearoylethanolamide | 2-Aminoethanethiol | MAZ51 | Costunolide | Enpp/Carbonic anhydrase-IN-2

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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