化合物 Mab?Aspartate Decarboxylase-IN-1 T60613

Product Introduction
Bioactivity


英文名: Mab Aspartate Decarboxylase-IN-1

描述: Mab Aspartate Decarboxylase-IN-1 是天冬氨酸脱羧酶 (PanD)的有效抑制剂(IC50 = 56.3 μM)，具有抗菌活性。

体外活性: Mab Aspartate Decarboxylase-IN-1 (compound analogue 2) shows inhibits against the mutants Mab PanDE119A, Mab PanDS135A and Mab PanDY126A mutants with the inhibition rates of 70.5%, 74.4%, 81.8%, respectively [1]. Mab Aspartate Decarboxylase-IN-1 (0-200 μM) shows inhibition on mycobacterium abscessus (Mab) PanD enzyme activity in the conversion of l-Asp to β-Ala with an IC 50 value of 56.3±4.8 μM [1]. Mab Aspartate Decarboxylase-IN-1 (0-4 mM) shows antibacterial activity for M. abscessus subsp. abscessus ATCC 19977 with an IC 50 value of 0.7mM, and M. abscessus subsp. bolletii CCUG 50184T, M. abscessus subsp. massiliense CCUG 48898T, M. abscessus subsp. abscessus Bamboo, M. abscessus subsp. abscessus ATCC 19977 with IC 50 s of 1-2 mM [1]. Mab Aspartate Decarboxylase-IN-1 shows mainly electrostatic- and hydrogen bonding interaction with the target enzyme [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途