化合物UK 383367 T6064
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 348622-88-8 | ¥333.00 | 询底价 |
1 mL | 348622-88-8 | ¥375.00 | 询底价 |
50 mg | 348622-88-8 | 面议 | 询底价 |
25 mg | 348622-88-8 | ¥793.00 | 询底价 |
10 mg | 348622-88-8 | ¥479.00 | 询底价 |
Product Introduction
Bioactivity
英文名: UK-383367
描述: UK-383367 是一种有效、选择性的 BMP-1 抑制剂,IC50=44 nM,对其选择性远高于 MMP 1,2,3,9 和 14。
体外活性: UK-383367 is effective at penetrating human skin. [1] UK-383367 inhibits collagen deposition with IC50 of ~2 μM. UK-383367 has modest affinity for all the PDE-4 subtypes PDE-4a, PDE-4b, PDE-4c and PDE-4d with IC50 of 1.8 μM, 1.5 μM, 2.4 μM and 0.9 μM, respectively. [2] UK-383367 is a weakly acidic compound and lipophilic. [3]
体内活性: Plasma protein binding values for UK-383367 in rat, dog and human are 95%, 93% and 94%, respectively. UK-383367 following incubation in rat plasma results in the half-life of 49?min. UK-383367 following single intravenous administration (2 mg/kg) to rat results in the plasma clearance of 157?mL min?1?kg?1, the volume of distribution of 12?L kg?1, and an elimination half-life of 0.8? hour. UK-383367 following single intravenous administration (0.5 mg/kg) to dog results in the plasma clearance of 35?mL min?1?kg?1, the volume of distribution of 4.6?L kg?1, and an elimination half-life of 1.5?hours. UK-383367 following oral administration (2 mg/kg) to dog results in Cmax of 110 ng/mL, Tmax of 0.5-1.5 hour and oral bioavilability of 13%. [3]
存储条件: keep away from direct sunlight,store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 65 mg/mL (200.38 mM)
DMSO : 65 mg/mL (200.38 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
关键字: inhibit | Inhibitor | UK-383367 | Procollagen C Proteinase | UK383367
相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途