化合物 Dobutamine T60677

Product Introduction
Bioactivity


英文名: Dobutamine

描述: Dobutamine 是合成儿茶酚胺，可增加心排血量，矫正低灌注。Dobutamine 作用于α1-AR,β1-AR 和β2-AR（α-1、β-1和β-2肾上腺素能受体），是 β1-AR 受体的选择性激动剂，对 α1-AR 和 β2-AR 活性相对较弱。

体内活性: Dobutamine has a rapid onset of action and a short half-life [2]. Dobutamine (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice [3]. Dobutamine results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice [3]. Low doses of Dobutamine significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice [3]. Dobutamine increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost [3]. Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation [4]. Animal Model: Tgαq*44 mice (heart failure models) [3] Dosage: 0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose Administration: Intraperitoneal injection Result: Induced different response in cardiac function on a low and high dose in mice with with heart failure.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途