化合物NVP-ADW742 T6079

Product Introduction
Bioactivity


英文名: NVP-ADW742

描述: NVP-ADW742 (ADW) 是一种具有口服活性，选择性的IGF-1R 酪氨酸激酶抑制剂，IC50为 0.17 μM。它抑制胰岛素受体，IC50为 2.8 μM，在肿瘤细胞中诱导多效性抗增殖/促凋亡。

体外活性: CRT0044876 potently inhibits the AP endonuclease, 3'-phosphodiesterase and 3'-phosphatase activities of APE1, and exhibits the selectivity for the inhibition of exonuclease III family. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds with an accumulation of unrepaired AP sites. [1] CRT0044876, by inhibition of the BER pathway increases oxidative DNA damage temporally related to increased intracellular reactive oxygen species in an acidic tumor microenvironment, and thus results in cell cycle arrests and increased DNA double strand breaks, leading to cell death. [2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 10 mg/mL (22.04 mM)
Ethanol : 3 mg/mL (6.61 mM)


关键字: NVP-ADW742 | inhibit | Apoptosis | Inhibitor | hematologic | multiple | NVP-ADW-742 | NVP ADW742 | NVPADW742 | ADW 742 | antiproliferative | tumor | Insulin Receptor | InsR | proapoptotic | myeloma | IGF-1R | ADW-742 | orally | malignancies | NVP-ADW 742 | solid | pleiotropic

相关产品: Brazilin | Indibulin | PR-619 | Voreloxin | TAI-1 | UC-514321 | Quercetin | Evocarpine | MKC-1 | Enpp/Carbonic anhydrase-IN-2

相关库: Glycometabolism Compound Library | Angiogenesis related Compound Library | Anti-Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Target-Focused Phenotypic Screening Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途