化合物 Cinnamyl-3,4-dihydroxy-α-cyanocinnamate T60860
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 132465-11-3 | ¥6,990.00 | 询底价 |
10 mg | 132465-11-3 | ¥1,550.00 | 询底价 |
2 mg | 132465-11-3 | ¥598.00 | 询底价 |
5 mg | 132465-11-3 | ¥987.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
描述: Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) 具有用于1型糖尿病的研究潜力,它是 12/15 脂氧合酶的有效抑制剂。
体外活性: High glucose or 12(S)-HETE remarkably increased transendothelial dextran transport, and in combination it was increased further. Addition of the 12/15-LO inhibitor, CDC, partially suppressed dextran transport [1].
体内活性: The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
化合物 Cinnamyl-3,4-dihydroxy-α-cyanocinnamate T60860信息由TargetMol中国为您提供,如您想了解更多关于化合物 Cinnamyl-3,4-dihydroxy-α-cyanocinnamate T60860报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途