化合物 NiCur T60888

Product Introduction
Bioactivity


英文名: NiCur

描述: NiCur 可阻断CBP HAT 活性并在基因毒性应激时下调 p53 的激活。NiCur 是CBP 组蛋白乙酰转移酶 (HAT)的有效选择性抑制剂，IC50值为 0.35 μΜ。 NiCur 可用于机制研究，不影响目标蛋白的表达。

体外活性: NiCur (0.5~1 μM; U2OS cells) reduces the Dox-induced p53K382ac, p53S15p, and p53 levels in a dose-dependent manner [1]. NiCur (1.5 μM) reduces the level of H3K27ac. NiCur (1.5 μM; U2OS cells) restores cellular proliferation. NiCur (Intestinal epithelial cells) down-regulates Dox-mediated p53 activation without affecting the levels of H2A.X S139p. NiCur can modulate the gene regulatory switch for reprogramming chromatin landscape. NiCur blocks CBP HAT activity [1]. Western Blot Analysis [1] Cell Line: U2OS cells Concentration: 0.5~1 μM Incubation Time: Result: Reduced the Dox-induced p53K382ac, p53S15p, and p53 levels in a dose-dependent manner.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途