化合物 U92016A hydrochloride T60990

Product Introduction
Bioactivity


英文名: U92016A hydrochloride

描述: U92016A hydrochloride 是口服有效的5-HT1A 受体激动剂，代谢稳定。U92016A hydrochloride 表现出极高的内在活性，能够以高亲和力结合中国仓鼠卵巢细胞中表达的人 5-HT1A 受体，Ki 值为0.2 nM。

体外活性: U92016A (U-92016A) is selective for the 5-HT1A receptor over other biogenic amine receptors. U92016A decreases the Forskolin-induced increase in cyclic AMP synthesis and has an intrinsic activity of 0.82 relative to 5-HT in Chinese hamster ovary cells expressing the human 5HT1A receptor [2].

体内活性: U92016A (U-92016A) potently decreases rectal temperature in mice. U92016A also elicits the 5-HT-mediated syndrome in rats and results in a dose-related decrease in 5-hydroxytryptophan accumulation. U92016A also decreases arterial blood pressure in spontaneously hypertensive rats and inhibits sympathetic nerve activity in cats. U92016A displays excellent potency and a long duration of action. U92016A also inhibits the firing of dorsal raphe 5-HT neurons and is active in two social interaction assays. The p.o. bioavailability of U92016A is 45% [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途