化合物 Topoisomerase I/II inhibitor 2 T61045

Product Introduction
Bioactivity


英文名: Topoisomerase I/II inhibitor 2

描述: Topoisomerase I/II inhibitor 2 (compound 1a) 可显著抑制小鼠模型中的异种移植肿瘤的生长，可用于肝癌治疗。Topoisomerase I/II inhibitor 2 是一种DNA 拓扑异构酶 I/II 的双重抑制剂。Topoisomerase I/II inhibitor 2 是有效的拓扑异构酶抑制剂，对LM9 细胞和Huh7 细胞的 IC50值分别为 6.83 μM 和9.82 μM 。

体外活性: Topoisomerase I/II inhibitor 2 (compound 1a) (0-150 μM; 72 hours) has favourable anti-proliferative activity in cancer cell lines, and better inhibitory activity on two human hepatocellular carcinoma cell lines (HuH7, LM9) [1]. Topoisomerase I/II inhibitor 2 (20 μM; 24 hours) has no damage to the DNA of HuH7 cells while some damage is noticed on LM9 cells [1]. Topoisomerase I/II inhibitor 2 (1.25-8 μM; 1-2 weeks) inhibits cell proliferation of LM9 and Huh7 in a concentration-dependent manner [1]. Topoisomerase I/II inhibitor 2 (1.25-8 μM; 24 hours) has a good inhibitory effect on the migration and invasion of LM9 and HuH7 cells with concentration-dependent manner [1]. Topoisomerase I/II inhibitor 2 (0-20 μM; 24 hours) can inhibit the expression of matrix metalloproteinases-9 (MMP-9) in LM9 and HuH7 cells [1]. Topoisomerase I/II inhibitor 2 (0-20 μM; 48 hours) inhibits cells proliferation by blocking cell cycle at the G 2 /M phase [1]. Topoisomerase I/II inhibitor 2 (3.5-20 μM; 48 hours) can injure mitochondrial function and induce cell apoptosis in a concentration-dependent manner [1]. Cell Proliferation Assay Cell Line: LM9, HuH7, SK-hep-1, HepG2, HT-29, HCT-116, RKO, SW480, MCF-7, MDA-B-231, HGC-27, SGC-7901, BGC-823, A549, U251, HL-60, LO2 [1] Concentration: 0-150 μM Incubation Time: 72 hours Result: Displayed favourable anti-proliferative activity and had better inhibitory activity on two human hepatocellular carcinoma cell lines (HuH7, LM9). Western Blot Analysis Cell Line: LM9 and HuH7 cells [1] Concentration: 0, 3.75, 7.5, 15 μM in LM9; 0, 5, 10, 20 μM in HuH7 Incubation Time: 48 hours Result: Inhibited the expression of MMP-9. Cell Cycle Analysis Cell Line: LM9 and HuH7 cells [1] Concentration: 0, 3.75, 7.5, 15 μM in LM9; 0, 5, 10, 20 μM in HuH7 Incubation Time: 48 hours Result: Inhibited cells proliferation by blocking cell cycle at the G 2 /M phase. Apoptosis Analysis Cell Line: LM9 and HuH7 cells [1] Concentration: 3.5, 7, 14 μM in LM9; 5, 10, 20 μM in HuH7 Incubation Time: 48 hours Result: Induced apoptosis in a dose-dependent manner.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途