几丁质合酶抑制剂4 T61147

Product Introduction
Bioactivity


英文名: Chitin synthase inhibitor 4

描述: Chitin synthase inhibitor 4 是一种具有抗菌活性的几丁质合成酶（CHS）抑制剂。Chitin synthase inhibitor 4 是一种基于CHS 的化合物，是一种候选的杀菌剂。

体外活性: Chitin synthase inhibitor 4 (compound 4fh) (50 μM; 3 h) exhibits inhibition against chitin synthase and polyoxin D with inhibition rates of 68.08% and 63.84%, respectively. Chitin synthase inhibitor 4 shows good antifungal activities against V. mali and S. sclerotiorum with EC50 values of 0.71 and 2.47 μg/mL, respectively. Chitin synthase inhibitor 4 (50 μg/mL) displays potency inhibition against V. mali and S. sclerotiorum with inhibition rates of 90.3% and 88.7%, respectively. Chitin synthase inhibitor 4 (1 μg/mL) blocks the hyphae growth, results abnormal growth, with inducing cell content decreasing, cell wall degradation, and plasmolysis.[1]

体内活性: Chitin synthase inhibitor 4 (compound 4fh) (Oral gavage; Rat with Salmonella typhimurium) has low acute toxicity, with no carcinogenic and mutagenic toxicity risk.[1]Chitin synthase inhibitor 4 (50 μg/mL) has considerable curative and protective effects against S. sclerotiorum vivo, and no obvious phytotoxicity.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (158.79 mM)


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相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途