化合物 Antibacterial agent 121 T61149

Product Introduction
Bioactivity


英文名: Antibacterial agent 121

描述: Antibacterial agent 121 (Compound 10) demonstrates antibacterial properties and exhibits efficacy against mycobacterial strains while also possessing anti-inflammatory activity. This compound finds potential applications in Tuberculosis (TB) research [1].

体外活性: Antibacterial agent 121 (0.2-200 μM; 24 h) inhibits M. tuberculosis H37Rv growth in bacterial culture [1]. Antibacterial agent 121 (0-200 μM; 24 h) inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC 50 value of 4.1 μM [1]. Antibacterial agent 121 (6.25-200 μM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages [1]. Antibacterial agent 121 (25-100 μM, 4 d) inhibits M. tuberculosis M299 with an MIC 50 value of 24.8 μM [1]. Cell Viability Assay [1] Cell Line: M. tuberculosis H37Rv Concentration: 0.2-200 μM Incubation Time: 24 hours Result: Inhibited Mtb H37Rv growth with MIC 50 of 8.6 μM. Cell Viability Assay [1] Cell Line: RAW 264.7 macrophages and J774A.1 macrophages Concentration: 6.25-200 μM Incubation Time: 24 hours Result: Showed IC 50 values of 15.3 μM and 28.4 μM for TNF-α and IL-1β production, respectively.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途