化合物 PAK4-IN-2 T61299

Product Introduction
Bioactivity


英文名: PAK4-IN-2

描述: PAK4-IN-2 is an exceptionally effective inhibitor of PAK4, exhibiting an IC 50 value of 2.7 nM. This compound is capable of arresting MV4-11 cells at the G0/G1 phase and inducing cell apoptosis. It holds significant potential in cancer research [1].

体外活性: PAK4-IN-2 (compound 5n) (0-10 μM; 72 hours) exhibits cell growth inhibition potency in hematoma tumor MV4-11 and solid tumor cell line MDA-MB-231, shows less sensitivity in normal human renal epithelial cell 239 T cell [1]. PAK4-IN-2 (5-50 nM; 48 hours) causes a majority of cells in G0/G1 phase with decreasing S-phase populations [1]. PAK4-IN-2 (10-250 nM; 48 hours) induces apoptosis in a dose-dependent manner [1]. PAK4-IN-2 (50-800 nM; 24 hours) markedly reduces the expression levels of p-PAK4(Ser474) in concentration dependently [1]. Cell Proliferation Assay Cell Line: MV4-11, MDA-MB-231 and 293T [1] Concentration: 0-10 μM Incubation Time: 72 hours Result: Exhibited significant cell growth inhibition potency in hematoma tumor MV4-11 (IC 50 = 7.8 ± 2.8 nM), and moderate potent anti-proliferative effect in solid tumor cell line MDA-MB-231 (IC 50 = 825 ± 106 nM), less sensitivity in normal human renal epithelial cell 239 T cell (IC 50 > 10000 nM). Cell Cycle Analysis Cell Line: MV4-11 [1] Concentration: 5, 10 and 50 nM Incubation Time: 48 hours Result: Caused a majority of cells in G0/G1 phase with decreasing S-phase populations. Apoptosis Analysis Cell Line: MV4-11 [1] Concentration: 10, 50 and 250 nM Incubation Time: 48 hours Result: Induced apoptosis in a dose-dependent manner. Western Blot Analysis Cell Line: MV4-11 [1] Concentration: 50, 200 and 800 nM Incubation Time: 24 hours Result: Markedly reduced the expression levels of p-PAK4(Ser474) in concentration dependently.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

化合物 PAK4-IN-2 T61299信息由TargetMol中国为您提供，如您想了解更多关于化合物 PAK4-IN-2 T61299报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途