BRD4抑制剂20 T61318

Product Introduction
Bioactivity


英文名: BRD4 Inhibitor-20

描述: BRD4 Inhibitor-20是一种有效的溴结构域蛋白4(BRD4)抑制剂，具有口服活性。BRD4 Inhibitor-20在癌细胞系中具有抗增殖活性，并被用于各种癌症的研究，如结肠癌。

体外活性: BRD4 Inhibitor-20 has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with IC50 values of 19 nM and 28 nM, respectively. BRD4 Inhibitor-20 has anti-proliferation potency with IC50 values of 4.75 μM, 1.35 μM and 44.07 μM in HT-29, HL-60 and WI-38 cells, respectively[1].

体内活性: 口服 BRD4 Inhibitor-20，15mg/kg表现出良好的口服药代动力学特性[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30 mg/mL (83.7 mM)


相关产品: A1874 | CBP/EP300-IN-1 | BET-IN-16 | ZEN-2759 | YHO-13351 | ZL0454 | ZEN-3862 | (R)-(-)-JQ1 Enantiomer | Bromodomain inhibitor-12 (edisylate) | BRD7-IN-2

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | PPI Inhibitor Library | Histone Modification Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途