化合物 Loxapine hydrochloride T61381
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 54810-23-0 | ¥13,800.00 | 询底价 |
100 mg | 54810-23-0 | ¥17,500.00 | 询底价 |
25 mg | 54810-23-0 | ¥10,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Loxapine hydrochloride
描述: Loxapine hydrochloride is a dibenzoxazepine anti-psychotic agent that exerts its effects through oral administration, functioning as an inhibitor of dopamine and an antagonist of 5-HT receptors [1] [4].
体外活性: In the presence of Loxapine, [ 3 H]ketanserin binds to 5-HT 2 receptor in Frontal cortex of brain in human and bovine with K i value of 6.2 nM and 6.6 nM, respectively. Loxapine has the rank order of potency for the various receptors appears to be as follows: 5-HT 2 ≥D 4 >>>D 1 >D 2 in comparing competition experiments involving the human membranes [1]. Loxapine (0-20 μM, 24 h or 72 h) reduces IL-1β secretion by LPS-activated mixed glia cultures, reduces IL-2 secretion in mixed glia cultures, and decreases IL-1β and IL-2 secretion in LPS-induced microglia cultures [2].
体内活性: Loxapine (5 mg/kg; i.p.; daily for 4 or 10 weeks) decreases serotonin (S 2 ) but does not elevate dopamine (D2) receptor numbers in the rat brain [3]. Animal Model: Adult male Wistar rats (150-175 g) [3] Dosage: 5 mg/kg Administration: Intraperitoneal injection, daily for 4 or 10 weeks Result: Induced a very significant reduction (more than 50%) of serotonin (S 2 ) receptor density after 4 weeks or 10 weeks of daily injection, but did not produce any significant increase in dopamine receptor density.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途