化合物 Z164597606 T61399

Product Introduction
Bioactivity


英文名: Z164597606

描述: Z164597606 is a compound that acts as a selective inhibitor of the enzyme Butyrylcholinesterase (BChE), with IC50 values of 1.3 μM and 1.7 μM for equine BChE and human BChE, respectively. Through a π-π stacking interaction, Z164597606 specifically interacts with the amino acid Trp82 of human BChE. This compound has potential applications in Alzheimer's disease research [1] [2].

体外活性: Z164597606 (10 μM) potently inhibits BChE activity, with no more than 30% inhibitory against ACHE [1]. Z164597606 (0.5-20 μM) may bind to catalytic “anionic” site (CAS) when interacting with BChE (determined by Lineweaver-Burk reciprocal plots) [1]. Z164597606 (10 and 50 μM) shows no toxicity on neuronal cell line SH-SY5Y [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途