化合物ZM 39923 HCl T6145

Product Introduction
Bioactivity


英文名: ZM39923 hydrochloride

描述: ZM39923 hydrochloride (JAK3 Inhibitor IV) 是一种 JAK3抑制剂，pIC50值为 7.1。它也抑制组织型转谷氨酞胺酶 (TGM2) 的活性，IC50值为 10 nM。

体外活性: The selectivity of Rotigotine for D3 (pKi 9.2) receptors is higher 10-fold than D2/D4/D5 (pKi 8.5-8.0) and 100-fold than D1 receptors (pKi 7.2). Rotigotine (10 μM) decreases the number of THir neurons by 40% in primary mesencephalic cell culture. In functional studies, Rotigotine behaves as a full agonist at all dopamine receptors but notably, the potency for stimulation of D1 receptors is similar to that for D2/D3 receptors (pEC50 respectively: 9.0, 9.4-8.6, 9.7). Rotigotine (0.01 μM) slightly protects dopaminergic neurons against MPP+ toxicity, significantly protects dopaminergic neurons against rotenone-induced cell death, and significantly inhibits ROS production by rotenone.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 8 mg/mL (21.74 mM)
DMSO : 28 mg/mL (76.1 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: inhibit | ZM39923 hydrochloride | ZM 39923 | Janus kinase | ZM-39923 hydrochloride | JAK | ZM39923 Hydrochloride | ZM-39923 | Inhibitor | ZM-39923 Hydrochloride | ZM 39923 Hydrochloride | ZM39923

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相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Lung Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Anti-Colorectal Cancer Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Pancreatic Cancer Compound Library | Stem Cell Differentiation Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途