化合物 VEGFR-2/DHFR-IN-1 T61489

Product Introduction
Bioactivity


英文名: VEGFR-2/DHFR-IN-1

描述: VEGFR-2/DHFR-IN-1 (compound 8b) 是 VEGFR-2和DHFR 的抑制剂，其IC50值分别为 0.384 和 7.881 μM。VEGFR-2/DHFR-IN-1 对大肠埃希菌，粪链球菌，肠沙门氏菌，金黄色酿脓葡萄球菌，MSSA 和MRSA 显示了良好的抗菌活性，MIC 值分别为 16，16，16，8 和 16 μg/mL。VEGFR-2/DHFR-IN-1 对 C26，HepG2 和 CF7 癌细胞系具有良好的细胞毒性，IC50值为 2.97-7.12 μM。VEGFR-2/DHFR-IN-1 可用于癌症的研究。

体外活性: VEGFR-2/DHFR-IN-1 (2-1024 μg/mL; 18-72 h) shows antibacterial and antifungal activities with MIC values of 16, 64, 16, 16, 8, 16, 64 and 256 μg/mL for Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, Salmonella enterica, MSSA, MRSA, Candida albicans and Aspergillus niger, respectively [1]. VEGFR-2/DHFR-IN-1 (0.5-100 μM; 48 h) exhibits anticancer activities [1]. VEGFR-2/DHFR-IN-1 (0-100 μM; 30 min) shows DHFR and VEGFR-2 inhibitory activities with IC 50 s of 7.881 and 0.384 μM, respectively [1]. Cell Cytotoxicity Assay [1] Cell Line: C26, HepG2, MCF7 and H69PR cell lines Concentration: 0.5, 1, 5, 10, 25, 50, 80 and 100 μM Incubation Time: 48 hours Result: Showed anticancer activities to C26, HepG2, MCF7 and H69PR cells with IC 50 s of 2.97, 7.12, 3.58 and 12.79 μM, respectively.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

化合物 VEGFR-2/DHFR-IN-1 T61489信息由TargetMol中国为您提供，如您想了解更多关于化合物 VEGFR-2/DHFR-IN-1 T61489报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途