化合物YH239-EE T6149

Product Introduction
Bioactivity


英文名: YH239-EE

描述: YH239-EE 是 YH239 的乙酯，是 p53-MDM2 拮抗剂和凋亡诱导剂。

细胞实验: Cell lines are harvested in log-phase growth and seeded following exposure to p53-MDM2 antagonists. Cell number and viability are determined by staining cells with Trypan blue 0.4% and counted with Countess slides.(Only for Reference)

体外活性: YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 15 mg/mL (29.7 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 93 mg/mL (184.4 mM)


关键字: Apoptosis | E2 conjugating enzyme | Ubiquitin activating enzyme | YH239 EE | E1/E2/E3 Enzyme | Ubiquitin conjugating enzyme | YH239-EE | E1 activating enzyme | E3 ligating enzyme | inhibit | Inhibitor | YH-239-EE | YH239EE | MDM-2/p53 | Ubiquitin ligase

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相关库: Glycometabolism Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Ubiquitination Compound Library | Ferroptosis Compound Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library | Autophagy Compound Library | Target-Focused Phenotypic Screening Library | Stem Cell Differentiation Compound Library

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