化合物 Medroxalol T61495

Product Introduction
Bioactivity


英文名: Medroxalol

描述: Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist that effectively blocks both α- and β-adrenergic receptors, effectively producing antihypertensive and vasodilating effects [1].

体外活性: Medroxalol (0.1-10 μM; 20 min) shows α- and β-adrenergic receptor antagonism in isolated rabbit aortic strip [1]. Cell Viability Assay [1] Cell Line: Isolated rabbit aortic strip Concentration: 0.1-10 μM Incubation Time: 20 min Result: Showed pA 2 values of 6.09 and 7.73 for α-adrenergic receptors and β-adrenergic receptors, respevtively.

体内活性: Medroxalol (oral gavage; 12.5-50 mg/kg; once daily; 12 d) treatment shows antihypertensive activity in spontaneously hypertensive rats [1]. Animal Model: Male spontaneously hypertensive rats (SHR) [1] Dosage: 12.5, 25, or 50 mg/kg Administration: Oral gavage; 12.5, 25, or 50 mg/kg; once daily; 12 days Result: Produced a dose-related fall in blood pressure.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途