化合物 Nrf2/HO-1 activator 2 T61522

Product Introduction
Bioactivity


英文名: Nrf2/HO-1 activator 2

描述: Nrf2/HO-1 activator 2 (compound 13m), a difluoro-substituted derivative, is a highly potent activator of Nrf2/HO-1. It exhibits substantial neuroprotective and antioxidant properties by activating the Nrf2/HO-1 pathway through phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. This compound finds utility in the investigation of Parkinson's disease (PD) [1].

体外活性: Nrf2/HO-1 activator 2 (compound 13m; 0.1-30 μM; 24 h) has protection to PC12 cells against toxicity and inhibits 6-OHDA- and Rotenone - induced cell death [1]. Nrf2/HO-1 activator 2 (1-100 μM; 11 h) inhibits 6-OHDA- or rotenone-induced production of reactive oxygen species and partially attenuates lipid peroxidation in rat brain homogenates. Nrf2/HO-1 activator 2 inhibits the production of lipid peroxide in rat brain homogenates by 28.8% at 100 μM [1]. Nrf2/HO-1 activator 2 (1-100 μM; 11 h) up-regulates heme oxygenase-1 (HO-1) and Nrf2 expression [1]. Nrf2/HO-1 activator 2 (10 μM; 2-3 h; PC12 cells) activator 2 activates Nrf2/HO-1 signaling by phosphorylated ERK1/2, JNK, and Akt [1]. Cell Viability Assay [1] Cell Line: PC12 cells Concentration: 3, 5, 7, 10 and 30 μM, 6-OHDA (50 μM); 0.1, 0.3, 1, 3, 10, and 30 μM, Rotenone (1 μM) Incubation Time: 24 hours Result: Exhibited neuroprotective effects on 6-OHDA-induced toxicity in dose-dependent manners. Rescued cells from rotenone-induced damage, with increased levels of cell viability up to 79.9% at 30 μM. Western Blot Analysis [1] Cell Line: PC12 cells Concentration: 0, 1, 3, 10, and 30 μM Incubation Time: 24 hours Result: Upregulated HO-1 levels in a dose-dependent manner, with 1.5- and 2-fold increases at 30 μM concentrations, respectively. Enhanced the nuclear translocation of Nrf2 in PC12 cells after 3 h at 10 μM. Western Blot Analysis [1] Cell Line: PC12 cells Concentration: 10 μM Incubation Time: 2-3 hours Result: Induced the phosphorylation of ERK1/2, JNK, and Akt.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途