化合物 Indomethacin sodium T61606
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 7681-54-1 | ¥10,600.00 | 询底价 |
100 mg | 7681-54-1 | ¥17,500.00 | 询底价 |
50 mg | 7681-54-1 | ¥13,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Indomethacin sodium
描述: Indomethacin sodium, a powerful and orally active inhibitor of COX1/2, exhibits IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Apart from its potent anti-inflammatory effects, this compound possesses notable anticancer and anti-infective activities. Since it has such versatile attributes, it finds useful applicability in cancer, inflammation, and viral infection research [1] [2] [3].
体外活性: Indomethacin (Indometacin) sodium (0-150 μM; 24 hours; 3LL-D122 cells) has anticancer activity in vitro [2]. Indomethacin (Indometacin) sodium (0-1000 μM) protects the host cells from damage caused by the virus through activates PKR, resulting in elF2α phosphorylation, and in turn shutting of translation of viral protein and inhibiting replication of the virus (IC 50 =2μM) [3]. Cell Viability Assay [2] Cell Line: 3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells) Concentration: 0, 20, 50, 100 and 150μM Incubation Time: 24 hours Result: Inhibited cell viability at 20 mM, with 50% inhibition at 60 nM. Cell Cycle Analysis [2] Cell Line: 3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells) Concentration: 0, 30 and 80μM Incubation Time: 24 hours Result: Decreased in the percentage of cells at the G2/M phase and increased in the percentage of cells at G1 phase.
体内活性: Indomethacin (Indometacin) sodium (0.01-10 mg/kg; p.o.; for 3 hours; male Sprague-Dawley rats) induces paw oedema and hyperalgesmeasurement dose-dependently reversed carrageenan-induced hyperalgesia [1]. Indomethacin (Indometacin) sodium (10 mg/mL; p.o.; daily, for 29 days; male C57BL/6J mice) inhibits tumor growth in vivo [2]. Animal Model: Male Sprague-Dawley rats [1] Dosage: 0.01-10 mg/kg Administration: Oral administration; for 3 hours Result: Inhibited the carrageenan-induced rat paw oedema (ED 50 =2.0 mg/kg) and hyperalgesia (ED 50 =1.5 mg/kg) in a dose-dependent manner. Animal Model: Male C57BL/6J mice [2] Dosage: 10 mg/mL Administration: Oral administration; daily, for 29 days Result: Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途