化合物MY10 T61678

Product Introduction
Bioactivity


英文名: MY10

描述: MY10 可以减弱了类似暴饮暴食的乙醇消耗和乙醇奖励。MY10 是一种有效且具有口服活性的的受体蛋白酪氨酸磷酸酶 (RPTPβ/ζ) 抑制剂。

体内活性: MY10 (20, 60, 100 mg/kg; oral gavage; 3 days; rat) reduced alcohol consumption in the alcohol operant self-administration paradigm (p = 0.040). In the DID-MSA paradigm, rats drank significantly less alcohol (p = 0.019) and showed a significant decrease in alcohol preference (p = 0.002). We observed that the longer the exposure to alcohol, the greater the suppressing effects of MY10 on alcohol consumption. It was demonstrated that the effects of MY10 were specific to alcohol since saccharin intake was not affected by MY10 (p = 0.804). MY10 prevented the alcohol-induced down-regulation of Ptprz1 (p = 0.004) and anaplastic lymphoma kinase (Alk; p = 0.013) expression.[2]

存储条件: keep away from direct sunlight,store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45.0 mg/mL (117.1 mM)


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相关库: Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途