化合物 Ibutilide T61685
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 122647-31-8 | ¥17,500.00 | 询底价 |
50 mg | 122647-31-8 | ¥13,800.00 | 询底价 |
25 mg | 122647-31-8 | ¥10,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Ibutilide
描述: Ibutilide (U70226E free base) is a potent antiarrhythmic compound that extends the action potential duration. It effectively blocks the rapidly activating delayed rectifier potassium current (I Kr ) in AT-1 cells [1].
体外活性: Ibutilide is a potent IKr blocker with EC 50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells [1]. Ibutilide blocks I Kr in cells expressing HERG+MDR1*1 to the same extent as cells expressing HERG alone (IC 50 : 22.5±0.9 vs 27.4±2.5 nM). However, cells expressing MDR1*7 show a marked resistance to Ibutilide (IC 50 : 105.3±1.42 nM vs 27.4±2.5 nM) [2].
体内活性: Ibutilide prolongs cardiac repolarization in vitro and in vivo [1]. Ibutilide infusions (administered cumulatively in three doses, 0.01, 0.02 and 0.05 mg/kg i.v., each as a 10-min infusion) results in both polymorphic and monomorphic non-sustained ventricular tachycardia [3]. Animal Model: Fifteen adult mongrel dogs of either sex [1] Dosage: 0.01, 0.02 and 0.05 mg/kg Administration: Infusion Result: The action potential duration at 90% (APD 90 ) prolongation with Ibutilide (0.01 mg/kg) was significantly greater in congestive heart failure (CHF) vs. controls. An increased dispersion of left–right ventricular APD90 was observed in CHF at 0.01 mg/kg, but not in controls.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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