化合物 SB 258741 hydrochloride T61724
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | 价格 | 操作 |
---|---|---|
100 mg | ¥17,500.00 | 询底价 |
50 mg | ¥13,800.00 | 询底价 |
25 mg | ¥10,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: SB 258741 hydrochloride
描述: SB 258741 hydrochloride is a potent antagonist of the 5-HT 7 receptor, designed specifically for studying schizophrenia [1].
体外活性: SB-258741 behaves as a partial inverse agonist, the antagonist potency (apparent pK B ) is 8.47 [2].
体内活性: SB 258741 (0-9.1 mg/kg; s.c.; once or daily for 3 days) shows antipsychotic effects in rats [1]. Animal Model: Male Wistar rats, 250 –300 g in the phencyclidine (PCP)-disrupted prepulse inhibition (PPI) and PCP-disrupted social interaction (SIT) paradigm, 200 – 250 g in the catalepsy, motility, and D-amphetamine hyperactivity paradigms [1] Dosage: 0.56, 2.3, 4.6 and 9.1 mg/kg Administration: Subcutaneous injection, once or daily for 3 days (social interaction test) Result: Reversed hyperactivity induced by D-amphet-amine over 0.56 mg/kg, and reduced motility at 4.6 and 9.1 mg/kg. Did not reverse D-Amphetamine-disrupted PPI, but enhanced PCP-disrupted PPI. Reduced PCP (2 mg/kg)-induced hyperactivity.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途