化合物INH6 T6180

Product Introduction
Bioactivity


英文名: INH6

描述: INH6 是一种有效的 Hec1 抑制剂，可选择性地破坏 Hec1/Nek2 相互作用并诱导染色体错位。它抑制HeLa 细胞生长的IC50值为2.4 μM。

细胞实验: Standard XTT assays with a four-day drug treatment procedure are performed to measure the dose-dependent cytotoxicity of INH analogs in cultured cells. Triplicate sets are measured and compiled for final data presentation. The assay is performed by using a commercial kit following the instructions. In principle, cells are plated on 96-well dishes one day before the drug treatment, followed by drug treatment on day 2 and XTT assay on day 5 after drug addition. The absorption at 595 nm is measured with a plate reader and converted to cell survival percentages in comparison to mock treated groups.(Only for Reference)

体外活性: INH6有效靶向Hec1/Nek2复合物进行降解，并在MDA-MB231、MDA-MB468、HeLa和K562细胞系中展现出强大的细胞杀伤活性，其IC50分别为1.7、2.1、2.4和2.5 μM。INH6还能在HeLa细胞中引发有丝分裂异常，并诱导细胞凋亡。[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 9 mg/mL (27.9 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 60 mg/mL (186.1 mM)


关键字: Apoptosis | INH6 | Inhibitor | INH 6 | inhibit | INH-6

相关产品: Dacomitinib | β-Elemonic Acid | ST1074 | Tomentosin | (R)-CR8 trihydrochloride | Pracinostat | Oxibendazole | Trabectedin | SNS-032 | HBDDE

相关库: Microtubule-Targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | PPI Inhibitor Library | Apoptosis Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途