化合物 Thiethylperazine T61915

Product Introduction
Bioactivity


英文名: Thiethylperazine

描述: Thiethylperazine 是一种吩噻嗪衍生物。Thiethylperazine 是具有口服活性的组胺H1受体和多巴胺D2受体拮抗剂。Thiethylperazine 也是选择性的ABCC1激活剂，可减少小鼠中的淀粉样 β (Aβ) 负荷。Thiethylperazine 具有抗精神病，止吐和抗菌作用。

体外活性: Thiethylperazine can enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively [3].

体内活性: Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) significantly reduces Aβ42 levels in young APP/PS1 mice [2]. Animal Model: Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) ( APP/PS1 ) mice [2] Dosage: 3 mg/kg Administration: Intramuscular injection; twice daily; for 30 days Result: Significantly reduced Aβ42 levels in APP/PS1 mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途