化合物Pomaglumetad methionil盐酸盐 T61972

Product Introduction
Bioactivity


英文名: Pomaglumetad methionil hydrochloride

描述: Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) (LY2140023 hydrochloride) 是的 LY404039 的蛋氨酸前药，具有口服活性。LY404039是一种选择性 mGlu2/3 受体激动剂。Pomaglumetad methionil hydrochloride 可用于精神分裂症的研究。

体外活性: Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 µM. LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2].

体内活性: Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (55.8 mM)


关键字: Pomaglumetad methionil Hydrochloride | LY 2140023 Hydrochloride | LY2140023 Hydrochloride | LY-2140023 Hydrochloride

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