化合物 Trichlormethiazide sodium T61983

Product Introduction
Bioactivity


英文名: Trichlormethiazide sodium

描述: Trichlormethiazide sodium 是口服有效的噻嗪类利尿剂，显示降压活性。在急性肾功能衰竭大鼠中，Trichlormethiazide sodium 可增加尿量、Na 和 K 排泄，并有改善肌酐清除率 (CCRE)。

体内活性: Trichlormethiazide (1 mg/kg; p.o.; once) sodium increases urinary volume, sodium and potassium excretion in rats [1]. Trichlormethiazide (10 mg/kg, i.v.; daily for 5 days) sodium significantly reduces mean arterial pressure (MAP) within 24 h in high salt intake (HS) rats receiving angiotensin II, but does not affect MAP in any other group [2]. Animal Model: Male Wistar rats, weighing 170-300 g [1] Dosage: 1 mg/kg Administration: Oral administration, once Result: Significantly increased potassium excretion in normal rats. Significantly increased urinary volume, sodium and potassium excretion in cisplatin-induced ARF (acute renal failures) rats. Animal Model: Male Sprague-Dawley rats (350-450 g) [2] Dosage: 10 mg/kg Administration: Intravenous injection, daily, for 15 days Result: Produced a significant fall in MAP in rats on combined angiotensin II and high salt intake.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

化合物 Trichlormethiazide sodium T61983信息由TargetMol中国为您提供，如您想了解更多关于化合物 Trichlormethiazide sodium T61983报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途