化合物CJJ300 T62483

Product Introduction
Bioactivity


英文名: CJJ300

描述: CJJ300 是一种转化生长因子-β（TGF-β）抑制剂（IC50 : 5.3 μM）。CJJ300 通过破坏 TGF-β-TβR-I-TβR-II 信号传导复合物的形成来抑制 TGF-β 信号传导。CJJ300 可抑制细胞迁移。

体外活性: CJJ300 (20, 40, and 80 µM, 2 h; Human A549 lung epithelial cells) inhibits the phosphorylation of intracellular mediators in the downstream TGF-β signaling pathways, significantly attenuated the increasement of P-Smad2/Smad3, P-Erk1/2, and P-Akt induced by TGF-β. Downregulated the expression of EMT-associated proteins, including fibronectin, α-SMA, and MMP-2 in a dose-dependent manner without cytotoxicity. CJJ300 disturbs protein-protein interactions and prevents TGF-β receptor dimerization (IC50 = 23.6 ± 5.8 µM). CJJ300 suppresses TGF-β induced cell migration.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 16.67 mg/mL (38.26 mM)


相关产品: Chromenone 1 | A 77-01 | ITD-1 | BIBF0775 | Halofuginone hydrobromide | 3,7-DMF | LY-364947 | SB-505124 | Disitertide acetate | RepSox

相关库: Bioactive Compounds Library Max | Inhibitor Library | TGF-beta/Smad Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途