STAT3抑制剂13 T62491
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 2248552-86-3 | ¥6,920.00 | 询底价 |
100 mg | 2248552-86-3 | ¥11,600.00 | 询底价 |
10 mg | 2248552-86-3 | ¥4,320.00 | 询底价 |
50 mg | 2248552-86-3 | ¥8,950.00 | 询底价 |
2 mg | 2248552-86-3 | ¥1,960.00 | 询底价 |
5 mg | 2248552-86-3 | ¥3,320.00 | 询底价 |
Product Introduction
Bioactivity
英文名: STAT3-IN-13
描述: STAT3-IN-13 是一种有效的 STAT3 抑制剂。STAT3-IN-13 具有抗增殖和抗癌活性,通过与 STAT3 SH2 结构域结合发挥作用。STAT3-IN-13 抑制 STAT3 Y705 的磷酸化,诱导细胞凋亡 ,抑制肿瘤细胞的生长和转移。STAT3-IN-13 可用于研究乳腺癌和肝癌。
体外活性: STAT3-IN-13 (compound 6f), over a period of 48 hours, demonstrates anti-proliferative activity with IC50 values of 0.25, 0.11, and 0.55 μM for 143B, HOS, and MG63 cells, respectively [1].In the concentration range of 0.001-100 μM, STAT3-IN-13 (compound 6f) binds to STAT3 and interacts with STAT3^586-685 in a concentration-dependent manner, with a KD of 0.96 μM [1].Over a period of 24 hours at concentrations ranging from 0 to 1.0 μM in 143B and HOS cells, STAT3-IN-13 (compound 6f) inhibits STAT3 Y705 phosphorylation and suppresses STAT3 in tumor cells [1].At concentrations ranging from 0 to 1.0 μM over 48 hours in 143B cells, STAT3-IN-13 (compound 6f) induces apoptosis in a dose-dependent manner [1].
体内活性: In vivo, STAT3-IN-13 (compound 6f), administered intraperitoneally at doses of 10-20 mg/kg twice daily for 4 weeks in nude mice, effectively blocks osteosarcoma growth and metastasis [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 80 mg/mL (183.28 mM)
相关产品: Manassantin A | Diosgenin | STAT3-IN-3 | Kurarinol | STAT6-IN-2 | SC-43 | Ochromycinone | ML115 | Ganoderic acid B | Niclosamide
相关库: Inhibitor Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途