波生坦 T6264

Product Introduction
Bioactivity


英文名: Bosentan

描述: Bosentan (Benzenesulfonamide) 是 endothelin-1 (ET)拮抗剂，在人的 SMC 细胞中，它能够作用于 ETA 受体(Ki:4.7 nM)和 ETB 受体(Ki:95 nM)。

细胞实验: Incubation solutions containing bosentan (1, 10 and 100 µM) are prepared in cell culture medium. On the sixth day of culturing of the sandwich-cultured hepatocytes, cell culture medium is removed from the wells and incubation solution containing bosentan is added to the cells. The cells were incubated with the solution for 24 h at 37°C. After the exposure, the incubation solution id removed and the cells are rinsed with Plus (+) or Minus (−) buffer. The buffer solution is then removed and the cells are incubated with fresh Plus (+) or Minus (−) buffer for 5 min at 37°C. Following this 5 minute incubation, the buffer solution is collected and any remaining buffer is removed. The cells are then washed three times with ice-cold Plus (+) buffer and the plates are frozen at −80°C until processed for bioanalysis. (Only for Reference)

体外活性: In vitro, bosentan has been shown to improve human endothelial cell and reduce neointimal and smooth muscle proliferation[3].

体内活性: In pigs in vivo, bosentan has been shown to partially restore hypoxia-induced reductions in nitric oxide[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 3 mg/mL (5.43 mM)
DMSO : 55 mg/mL (99.71 mM)


关键字: Bosentan | Inhibitor | inhibit | Endothelin Receptor

相关产品: IRL-1620 acetate | Macitentan | SB-209670 | Zibotentan | BQ-3020 ammonium | Ambrisentan | Aminaftone | Aprocitentan | Enrasentan | RO 46-8443

相关库: Drug Repurposing Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Pediatric Drug Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途