头孢噻呋盐酸盐 T6268
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
200 mg | 103980-44-5 | ¥482.00 | 询底价 |
25 mg | 103980-44-5 | ¥157.00 | 询底价 |
100 mg | 103980-44-5 | ¥344.00 | 询底价 |
1 mL | 103980-44-5 | ¥197.00 | 询底价 |
50 mg | 103980-44-5 | ¥223.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Ceftiofur hydrochloride
描述: Ceftiofur hydrochloride (U-67279A) 是头孢噻呋的盐酸盐形式,是一种β-内酰胺酶稳定的半合成广谱头孢菌素,具有抗菌活性。
体外活性: Ceftiofur can downregulate tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6), but did not affect interleukin-10 (IL-10) production. Ceftiofur significantly inhibits extracellular signal-regulated kinase (ERK), p38, and c-jun NH(2)-terminal kinase (JNK) phosphorylation protein expression in RAW 264.7 cells. Ceftiofur also inhibits p65-NF-kappaB translocation into the nucleus in RAW 264.7 cells. [1]
体内活性: Ceftiofur treatment is associated with a significant decrease in rectal temperature and diarrhea in neonatal calves. Ceftiofur results in a significant decrease in fecal shedding of Salmonella organisms in neonatal calves. [2] Ceftiofur hydrochloride (intrauterine (i.u.)) reduces the prevalence of positive uterineculture in cows with clinical endometritis (29.0 vs. 51.4%) and reduces the overall prevalence of Arcanobacterium pyogenes (1.0 vs. 7.6%) at 51 d in milk (DIM) . Ceftiofur hydrochloride reduces the prevalence of uterine infection in cows with clinical endometritis, and the prevalence of A. pyogenes, but does not affect the prevalence of subclinical endometritis or fertility of dairy cows already receiving PGF(2alpha). [3] Ceftiofur hydrochloride (i.m. injection) results in C(max) of 11.8 mg/mL at 1-4 hours after injection, the mean area under the curve (AUC) of 216 m g x h/mL in pigs. [4] Ceftiofur hydrochloride (2.2 mg of CE/kg, SC or IM, once daily for 5 days) is efficacious for treatment of acute postpartum metritis (APM) in dairy cows. [5]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 21 mg/mL (37.5 mM)
DMSO : 93 mg/mL (166.1 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
关键字: Antibiotic | inhibit | Inhibitor | Ceftiofur | Bacterial | Ceftiofur Hydrochloride | Excenel Hydrochloride | Ceftiofur hydrochloride
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途