化合物Givinostat hydrochloride T6279L

Product Introduction
Bioactivity


英文名: Givinostat hydrochloride

描述: Givinostat hydrochloride (ITF2357 hydrochloride) 是一种 HDAC 抑制剂，对 HDAC1 和 HDAC3 的 IC50 分别为 198 和 157 nM。 Givinostat hydrochloride 具有抗炎、抗血管生成和抗肿瘤活性。

体外活性: Givinostat hydrochloride inhibits JS-1 cell proliferation in a concentration-dependent manner. Givinostat hydrochloride (≥500 nM) is associated with significant inhibition of JS-1 cell proliferation. Also, the cell inhibition rate significantly differs between the group cotreated with Givinostat hydrochloride ≥250 nM plus LPS and the group without LPS treatment[3]. Givinostat hydrochloride (25, 50, and 100 nM) reduces IL-1β secretion more than 70%. Givinostat hydrochloride suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM, but at 100 and 200 nM, there is no reduction[4].

体内活性: Givinostat hydrochloride（10 mg/kg）能降低血清TNFα 60%。预处理Givinostat hydrochloride（0.1 mg/kg）可显著降低循环中的TNFα，减少近90%[4]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 27.5 mg/mL (60.05 mM)


关键字: inhibit | Givinostat hydrochloride | Givinostat Hydrochloride | ITF-2357 Hydrochloride | Histone deacetylases | ITF 2357 Hydrochloride | Givinostat | Inhibitor | ITF2357 Hydrochloride | HDAC

相关产品: Bocodepsin | CG347B | Mz325 | HDACs/mTOR Inhibitor 1 | HDAC8-IN-20a | FT895 | BRD 9757 | Dacinostat | PB131 | HDAC/BET-IN-1

相关库: Drug Repurposing Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Anti-Pancreatic Cancer Compound Library | Histone Modification Compound Library | Bioactive Compound Library

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