Tau蛋白聚集体和神经炎症抑制剂1 T62899

Product Introduction
Bioactivity


英文名: Tau-aggregation and neuroinflammation-IN-1

描述: Tau-aggregation and neuroinflammation-IN-1 是一种有效的 Tau 蛋白聚集体抑制剂， 对 AcPHF6 和全长 tau 蛋白聚集体显示出显著的抑制活性。Tau-aggregation and neuroinflammation-IN-1具有抗炎活性且可减少 NO 释放。Tau-aggregation and neuroinflammation-IN-1 对 LSP 刺激的 BV2 细胞具有低细胞毒性。Tau-aggregation and neuroinflammation-IN-1 可逆转冈田酸诱导的大鼠记忆障碍。

体外活性: Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM. It does not show significant hepatotoxicity at high concentrations in LO2 cells, nor does it have any effect on the viability of BV2 cells at 20 μM.[1]Tau-aggregation and neuroinflammation-IN-1 (2.5, 5, and 10 μM; 24 h) maintain the anti-inflammatory effect of sodium usage and reduce the NO release rate by 41% at 10 μM in LPS-stimulated BV2 cells.[1]

体内活性: Tau-aggregation and neuroinflammation-IN-1（5和10 mg/kg；腹腔注射；连续7天，OA注射后继续腹腔注射7天；雄性SD大鼠）显著改善了OA诱导的大鼠常规参考空间记忆和认知能力。[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40.04 mg/mL (100 mM)


相关产品: Auristatin F | Vinorelbine ditartrate | Podofilox | Vinorelbine | Vindoline | Docetaxel trihydrate | INH6 | Thiabendazole | N-[2-(5-Chloro-1H-indol-3-yl)ethyl]-4'-cyanobiphenyl-2-carboxaMide | Verubulin

相关库: Microtubule-Targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

Tau蛋白聚集体和神经炎症抑制剂1 T62899信息由TargetMol中国为您提供，如您想了解更多关于Tau蛋白聚集体和神经炎症抑制剂1 T62899报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途