阿米卡星硫酸盐 T6382

Product Introduction
Bioactivity


英文名: Amikacin disulfate

描述: Amikacin disulfate (BAY-416651 sulfate) 是氨基糖苷类抗生素，也是卡那霉素的半合成类似物。它具有杀菌作用，直接作用于 30S 和 50S 细菌核糖体亚基，可抑制蛋白质合成。它对大多数革兰氏阴性细菌都有效。它还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。

体外活性: Amikacin sulfate has high affinities for 16S rRNA of the bacterial 30S ribosome, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. [1] Amikacin is active in vitro against Pseudomonas species, [2] Escherichia coli[3], Proteus species (indole-positive and indole-negative), Providencia species, Klebsiella-Enterobacter-Serratia species, Acinetobacter (formerly Mima-Herellea) species, and Citrobacter freundii.[4] [5] In vitro studies have shown that amikacin sulfate combined with a beta-lactam antibiotic acts synergistically against many clinically significant Gram-negative organisms. In vitro studies have shown that amikacin sulfate combined with beta-lactam antimicrobial agents including moxalactam or piperacillin acts synergistically against many clinically significant Gram-negative organisms. [6]

体内活性: Amikacin (80 mg/kg i.v.) significantly reduced pseudomonal densities within aortic vegetations compared to controls in the experimental rabbit endocarditis model. In addition, amikacin given once daily is still more effective than the twice-daily regimen. [7] Amikacin given alone at a dose of 50 mg/kg, in one, two, or three divided doses, showed remarkable activity in model of Mycobacterium avium complex infections in beige mice. Addition of clofazimine increased the activity significantly. [8]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 10 mM
DMSO : Insoluble


关键字: Bacterial | Amikacin Sulfate | bacillary | aminoglycosides | Gram-negative | ototoxic | Inhibitor | BAY 41-6551 disulfate | Amikacin disulfate | BAY-416651 Sulfate | Amikacin Disulfate | ribosomal | Antibiotic | synthesis | Amikacin | kanamycin | BAY 416651 Sulfate | infections | protein | Antimicrobial | inhibit | BAY416651 Sulfate

相关产品: Glabridin | NITD-349 | Morusin | FPI-1523 sodium | Gatifloxacin hydrochloride | c-Met-IN-15 | Sulfisoxazole acetyl | Thiolutin | Lansoprazole | D-Ribonolactone

相关库: Drug Repurposing Compound Library | Approved Drug Library | Antibiotics Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | EMA Approved Drug Library | Anti-Bacterial Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途